Associations of High-Density Lipoprotein Functionality with Coronary Plaque Characteristics in Diabetic Patients with Coronary Artery Disease: Integrated Backscatter Intravascular Ultrasound Analysis

High-density lipoprotein (HDL) functionality has been reported to be associated with coronary artery disease (CAD). However, little is known about the impact of HDL on atherosclerosis. Thirty-eight type 2 diabetic patients CAD who underwent percutaneous intervention were examined. Coronary atheroma burden and plaque composition culprit lesions assessed using conventional gray-scale integrated backscatter intravascular ultrasound. HDL-mediated cholesterol efflux capacity (HDL-CEC) antioxidant capacity, estimated as inflammatory index (HII), The associations between plaques analyzed multivariate data analysis, including principal components analysis orthogonal partial least squares (OPLS) models. Percent volume was correlated HDL-CEC (r = 0.34, p 0.04) but not HII (p 0.65). OPLS model demonstrated that percentage lipid significantly [coefficient (95% confidence interval); HDL-CEC: −0.26 (−0.49, −0.04); HII: 0.34 (0.08, 2.60), respectively]. exhibited highest variable importance in projection score, indicating greatest contribution. composition, a key component vulnerability. Our findings highlight potential for stabilization.